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[ 1 H, 15 N] NMR Studies of the Platination of Phosphorothioate Nucleotides − Monofunctional Sulfur Adducts versus Macrochelation
Author(s) -
Kratochwil Nicole A.,
Parkinson John A.,
Sacht Cheryl,
Murdoch Piedad del Socorro,
Brown Tom,
Sadler Peter J.
Publication year - 2001
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/1099-0682(200111)2001:11<2743::aid-ejic2743>3.0.co;2-z
Subject(s) - chemistry , guanosine , adduct , guanine , nucleotide , stereochemistry , oligonucleotide , sulfur , nuclear magnetic resonance spectroscopy , crystallography , dna , gene , organic chemistry , biochemistry
cis ‐[PtI 2 ( 15 NH 3 ) 2 ] reacts rapidly with guanosine‐5′‐ O ‐(2‐thiodiphosphate) (GDP‐β‐S) to form a macrochelate in which Pt bridges the phosphorothioate S and guanine N7 atoms. Phosphorothioate(α‐S)‐containing self‐complementary decamer oligonucleotides give rise to relatively long lived S‐bound monofunctional adducts, the fate of which is sequence dependent.