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Iron(III) Complexation by New Aminocarboxylate Chelators − Thermodynamic and Kinetic Studies
Author(s) -
Serratrice Guy,
Galey JeanBaptiste,
Aman Eric Saint,
Dumats Jacqueline
Publication year - 2001
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/1099-0682(200102)2001:2<471::aid-ejic471>3.0.co;2-a
Subject(s) - chemistry , ethylenediamine , potentiometric titration , ferric , ligand (biochemistry) , redox , aqueous solution , chelation , kinetics , inorganic chemistry , medicinal chemistry , reaction rate constant , dissociation (chemistry) , stereochemistry , organic chemistry , ion , biochemistry , physics , receptor , quantum mechanics
The complexation of Fe III by new tetradentate and pentadentate aminocarboxylate chelators, designed to protect cells against iron‐catalysed oxidative damage, was investigated. Ferric iron complexes of N , N′ ‐bis(3,4,5‐trimethoxybenzyl)ethylenediamine‐ N , N′ ‐diacetic acid ( L1 ), N , N′ ‐dibenzylethylenediamine‐ N , N′ ‐diacetic acid ( L2 ) and [ N ‐(2‐hydroxybenzyl)‐ N′ ‐benzylethylenediamine‐ N , N′ ‐diacetic acid] ( L3 ) have been characterized in aqueous solution by potentiometric, UV/Vis spectrophotometric and cyclic voltammetric measurements. The parent ligand, ethylenediamine‐ N , N′ ‐diacetic acid ( L4 ), has also been studied. As expected, the presence of a hard phenolate donor group in L3 significantly enhances the affinity for iron while decreasing the potential of the Fe III /Fe II redox couple compared to L1 or L2 . Kinetics studies have provided the kinetic rate constants related to the formation and the dissociation of the ferric complex with L3 . The results reveal a fast Fe III uptake, which is a favorable feature for a biological use of this type of ligand. Overall, these results demonstrate the pertinence of the use of such ligands to protect biological tissues against oxidative stress.