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Biomimetic Zinc Complexes With A New Tripodal Nitrogen‐Donor Ligand: Tris[2‐(1‐methyl‐4‐tolylimidazolyl)phosphane] (Pim Me, p Tol )
Author(s) -
Kläui Wolfgang,
Piefer Claudia,
Rheinwald Gerd,
Lang Heinrich
Publication year - 2000
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/1099-0682(200007)2000:7<1549::aid-ejic1549>3.0.co;2-#
Subject(s) - chemistry , tris , zinc , nitrogen , ligand (biochemistry) , tripodal ligand , medicinal chemistry , stereochemistry , organic chemistry , receptor , biochemistry
The new potentially threefold‐chelating ligand tris[2‐(1‐methyl‐4‐tolylimidazolyl)]phosphane (Pim Me, p Tol ) has been prepared. The p ‐tolyl substituents on the imidazole rings form a shielded hydrophobic cavity. The first X‐ray‐structure analysis of this ligand system confirms the proposed structure. The reaction of Pim Me, p Tol with ZnX 2 salts (X = Cl, Br, I, NO 3 ) yields monomeric Zn II complexes. The X‐ray crystal structures of [Pim Me, p Tol ZnCl] 2 (ZnCl 4 ) and [Pim Me, p Tol ZnNO 3 ]NO 3 prove that the Zn 2+ centres are in a tetrahedral environment with threefold N ‐imidazole coordination. This arrangement mimics the active centre of carbonic anhydrase (CA).