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Adult‐type pulmonary function tests in infants without respiratory disease
Author(s) -
Castile Robert,
Filbrun David,
Flucke Robert,
Franklin Wayne,
McCoy Karen
Publication year - 2000
Publication title -
pediatric pulmonology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.866
H-Index - 106
eISSN - 1099-0496
pISSN - 8755-6863
DOI - 10.1002/1099-0496(200009)30:3<215::aid-ppul6>3.0.co;2-v
Subject(s) - medicine , functional residual capacity , lung volumes , pulmonary function testing , vital capacity , cardiology , respiratory disease , respiratory system , lung , respiratory physiology , anesthesia , lung function , diffusing capacity
A new method that permits the measurement of adult‐type maximal expiratory flow‐volume curves and fractional lung volumes in sedated infants was recently described. The purpose of this study was to define the normal range for these new measures of pulmonary function in infants and young children. Measurements of forced expiratory flows and fractional lung volume were made on 35 occasions in 22 children (ages 3–120 weeks) without respiratory disease. Maximal expiratory flow‐volume curves were measured by the raised lung volume, thoracoabdominal compression technique. Functional residual capacity (FRC) was measured plethysmographically. Measurements of total lung capacity (TLC), residual volume (RV), FRC, forced vital capacity (FVC), and forced expiratory flows at 25, 50, 75, 85, and between 25% and 75% of expired FVC (FEF 25 , FEF 50 , FEF 75 , FEF 85 , and FEF 25–75 , respectively) all increased in relation to infant length ( P < 0.001). RV/TLC, FRC/TLC, and FEF 25–75 /FVC declined in relation to increasing length ( P < 0.001). The forced expiratory flow and fractional lung volume measurements using this method were similar to previously reported estimates using other methods. These estimates represent a reasonable reference standard for infants and young children with respiratory problems. Pediatr Pulmonol. 2000;30:215–227. © 2000 Wiley‐Liss, Inc.