Open AccessSerum cystatin C may predict the prognostic stages of patients with IgA nephropathy prior to renal biopsy
Author(s) -
Tomino Yasuhiko,
Suzuki Shigenobu,
Gohda Tomohito,
Kobayashi Michimasa,
Horikoshi Satoshi,
Imai Hirokazu,
Saito Takao,
Kawamura Tetsuya,
Yorioka Noriaki,
Harada Takashi,
Yasumoto Yuichiro,
Kida Hiroshi,
Kobayashi Yutaka,
Endoh Masayuki,
Sato Hidetoshi,
Saito Kensuke
Publication year - 2001
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/1098-2825(2001)15:1<25::aid-jcla5>3.0.co;2-y
Subject(s) - cystatin c , nephropathy , medicine , creatinine , renal function , gastroenterology , cystatin , renal biopsy , biopsy , endocrinology , diabetes mellitus
The relationship between the levels of serum cystatin C and the prognostic stages of IgA nephropathy was determined in a multicenter trial in Japan. The levels of serum cystatin C in patients with IgA nephropathy were measured using the Dade Behring N Latex Cystain C assay. In 1995, the Joint Committee of the Special Study Group on Progressive Glomerular Diseases, Ministry of Health and Welfare of Japan, and the Japanese Society of Nephropathy reported four prognostic stages. These are: good prognosis group (Group I), relatively good prognosis group (Group II), relatively poor prognosis group (Group III), and poor prognosis group (Group IV), for this disease. Three‐hundred and six patients with IgA nephropathy and other glomerular diseases were examined. There were no significant changes in the levels of serum creatinine (Cr) or creatinine clearance (CCr) between Group I and Group II. The mean levels of serum cystatin C in Group II were significantly higher than those in Group I ( P < 0.05). The mean levels of serum cystatin C in Group III or IV were significantly higher than those in Group I ( P < 0.001, P < 0.005, respectively). These suggest that the measurement of serum cystatin C may predict the prognostic stages of patients with IgA nephropathy prior to renal biopsy. J. Clin. Lab. Anal. 15:25–29, 2001. © 2001 Wiley‐Liss, Inc.