Open AccessACE and AT1R gene polymorphisms and hypertension in Indian population
Author(s) -
Ashavaid T.F.,
Shalia K.K.,
Nair K.G.,
Dalal J.J.
Publication year - 2000
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/1098-2825(2000)14:5<230::aid-jcla6>3.0.co;2-u
Subject(s) - genotype , medicine , blood pressure , allele , angiotensin converting enzyme , angiotensin ii , endocrinology , population , allele frequency , renin–angiotensin system , polymorphism (computer science) , essential hypertension , family history , genetics , biology , gene , environmental health
The renin angiotensin system (RAS) controls intrarenal blood pressure and sodium balance, and is an important target for antihypertensive therapy. Several polymorphisms have been identified within genes encoding RAS that may contribute to the development of elevated blood pressure. The relevance of these polymorphisms in hypertension remains controversial. In this study we have examined 105 hypertensive subjects and 192 controls from the Indian population for I/D polymorphism of angiotensin I converting enzyme (ACE) and A 1166 C polymorphism of angiotensin II type I receptor (AT1R) genes by polymerase chain reaction (PCR) and PCR‐based restriction enzyme analysis method, respectively. There was no significant difference in the distribution of ACE (I/I, I/D, and D/D) and AT1R (A/A and A/C) genotypes between controls and hypertensive subjects. D allele was significantly associated with an early onset of hypertension and although nonsignificant, the frequency was high in subjects with family history of cardiovascular disorders. C 1166 allele of AT1R did not correlate with the age of onset of hypertension and the frequency was low in subjects with family history. Thus no association was found between ACE and AT1R genotypes and hypertension. However the D allele can be used as a predictor of risk of hypertension in the Indian population. J. Clin. Lab. Anal. 14:230–237, 2000. © 2000 Wiley‐Liss, Inc.