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Expression and localization of prohormone convertase 1/3 (SPC3) in porcine ovary
Author(s) -
Renegar Randall H.,
Owens Charles R.,
Dai Guoli,
McMurtry John P.,
Kwok Simon C.M.
Publication year - 2000
Publication title -
molecular reproduction and development
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.745
H-Index - 105
eISSN - 1098-2795
pISSN - 1040-452X
DOI - 10.1002/1098-2795(200012)57:4<361::aid-mrd8>3.0.co;2-t
Subject(s) - biology , relaxin , corpus luteum , ovary , prohormone convertase , in situ hybridization , messenger rna , andrology , luteal phase , ribonuclease , gene expression , prohormone , medicine , endocrinology , microbiology and biotechnology , gene , rna , hormone , genetics
Tissue distribution and cellular localization of PC1/3 mRNA in porcine tissues were examined by ribonuclease protection assay and in situ hybridization. PC1/3 mRNA was detected mainly in the corpus luteum of pregnant sow and brain. Within the ovary, PC1/3 and relaxin transcripts colocalized within large luteal cells. Levels of PC1/3 transcripts in corpora lutea increased as gestation advanced, parallel with an observed increase in relaxin transcripts. A role for PC1/3 in proprotein processing in the ovary is discussed. Mol. Reprod. Dev. 57:361–365, 2000. © 2000 Wiley‐Liss, Inc.