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Opiate receptor avidity in the thalamus is sexually dimorphic in the elderly
Author(s) -
Cohen Robert M.,
Carson Richard E.,
Sunderl Trey
Publication year - 2000
Publication title -
synapse
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.809
H-Index - 106
eISSN - 1098-2396
pISSN - 0887-4476
DOI - 10.1002/1098-2396(200011)38:2<226::aid-syn13>3.0.co;2-#
Subject(s) - avidity , opiate , thalamus , alzheimer's disease , sexual dimorphism , medicine , antagonist , psychology , receptor , endocrinology , disease , neuroscience , immunology , antibody
Opiate receptor avidity (B ′ max /K D ), was measured in the subcortex of nine females (five healthy subjects, four Alzheimer patients) and 15 males (seven healthy subjects, eight Alzheimer patients), 51–75 years of age, with the opiate receptor antagonist 6‐deoxy‐6‐β‐[ 18 F]fluoronaltrexone (cyclofoxy, CF) and a positron emission tomograph. CF avidity was 27.5% less in the thalamus of healthy women compared to healthy men and 48.5% less in Alzheimer disease female patients compared to male patients. Synapse 38:226–229, 2000. © 2000 Wiley‐Liss, Inc.