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Fighting experiences and natural killer cell activity in male laboratory mice
Author(s) -
Azpiroz Aranzazu,
Arregui Amaia,
Fano Eduardo,
Garmendia Larraitz,
Ramón SánchezMartin José
Publication year - 1994
Publication title -
aggressive behavior
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.223
H-Index - 92
eISSN - 1098-2337
pISSN - 0096-140X
DOI - 10.1002/1098-2337(1994)20:1<67::aid-ab2480200108>3.0.co;2-d
Subject(s) - agonistic behaviour , aggression , immune system , cytotoxic t cell , psychology , natural killer cell , immunosuppression , immunology , biology , developmental psychology , genetics , in vitro
There is currently much interest in the potential impact of psychological factors on immune responses. An attempt was made to assess the effects of dominant/subordinate polarity in male mice on the cytotoxic activities of their natural‐killer (NK) cells. On the basis of repeated agonistic encounters, categories of subordinate and dominat animals were selected. These animals were compared with manipulated controls (introduced to a novel test cage without an opponent on each occasion) and undisturbed controls (who remained in isolation without manipulation). In terms of NK activity, immunosuppression was observed in both dominant and subordinate categories when compared to undisturbed controls. There were, however, no differences between the fighting exposed subjects and the manipulated controls, suggesting that stress accounts for any changes. © 1994 Wiley‐Liss, Inc.