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Effects of alpha and beta adrenergic antagonists on aggressive behavior in male mice
Author(s) -
AlMaliki Sami J.,
AlHamood Mohammed H.
Publication year - 1993
Publication title -
aggressive behavior
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.223
H-Index - 92
eISSN - 1098-2337
pISSN - 0096-140X
DOI - 10.1002/1098-2337(1993)19:5<361::aid-ab2480190505>3.0.co;2-m
Subject(s) - phentolamine , yohimbine , prazosin , aggression , atenolol , alpha (finance) , endocrinology , propranolol , adrenergic receptor , medicine , clonidine , psychology , beta (programming language) , adrenergic , antagonist , pharmacology , receptor , developmental psychology , construct validity , computer science , blood pressure , programming language , psychometrics
The effects of a variety of alpha and beta adrenergic antagonists were examined on the social encounters of isolated male mice with anosmic male partners. A range of alpha antagonists, including phentolamine, prazosin, and yohimbine, all suppressed social aggression. A range of beta antagonists, including propranolol, atenolol, metaprolol, and ICI 118, 551, also reduced this type of attack. Ethological assessment of the lowest effective dose of these adrenergic antagonists revealed a marked inhibitor action on offensive, social, and nonsocial behavior, while defensive responses and immobility were enhanced. It is concluded that the noradrenergic system has a significant non‐specific role in mediating intermale aggression via both alpha and beta adrenergic receptor subtypes. © 1993 Wiley‐Liss, Inc.