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Role of serotonin in human aggressive behaviour
Author(s) -
Marazziti Donatella,
Rotondo Alessandro,
Presta Silvio,
PancioliGuadagnucci Maria Laura,
Palego Lionella,
Conti Luciano
Publication year - 1993
Publication title -
aggressive behavior
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.223
H-Index - 92
eISSN - 1098-2337
pISSN - 0096-140X
DOI - 10.1002/1098-2337(1993)19:5<347::aid-ab2480190503>3.0.co;2-c
Subject(s) - serotonergic , imipramine , serotonin , abnormality , platelet , poison control , medicine , psychology , endocrinology , suicide attempt , injury prevention , psychiatry , clinical psychology , medical emergency , pathology , receptor , alternative medicine
This study aimed to evaluate a peripheral serotonergic marker, 3 H‐imipramine ( 3 H‐IMI) binding to platelet membranes, in a group of severely aggressive subjects (A), institutionalized since childhood for mental retardation, as compared with suicide attempters (S) and healthy controls (H). The maximum binding capacity of 3 H‐IMI to platelet membranes was statistically lower in (A) and (S) than in (H). In addition, a statistically significant difference was observed between the Bmax values of aggressive subjects and those of suicide attempters. No changes in the dissociation constant (Kd) of IMI binding were observed. These data provide further supporting evidence for the hypothesis of an abnormality of the 5HT system in aggressive behaviour and suggest that such an abnormality, as reflected by platelet markers, is more severe in suicide attempters. © 1993 Wiley‐Liss, Inc.