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Role of 5HT 1A receptors in a variety of kinds of aggressive behavior in wild rats and counterparts selected for low defensiveness towards man
Author(s) -
Nikulina Ella M.,
Avgustinovich Damira F.,
Popova Nina K.
Publication year - 1992
Publication title -
aggressive behavior
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.223
H-Index - 92
eISSN - 1098-2337
pISSN - 0096-140X
DOI - 10.1002/1098-2337(1992)18:5<357::aid-ab2480180505>3.0.co;2-c
Subject(s) - ipsapirone , aggression , neophobia , receptor , domestication , medicine , endocrinology , agonist , serotonin , 5 ht receptor , hypothalamus , psychology , chemistry , biology , developmental psychology , ecology
The 5HT 1A receptor agonist ipsapirone (10 mg/kg) suppressed shock‐induced aggression in wild and domesticated rats but did not affect predatory aggression in either group of animals. Ipsapirone decreased neophobia and inhibited defensive reactions by wild rats towards man in the glove test. [ 3 H]8‐OH‐DPAT binding, which labels 5HT 1A receptors, was significantly increased in the hypothalamus of domesticated rats in comparison with wild counterparts, while 5HT 1A density was unchanged in the frontal cortex in domesticated animals. In essence, the aggressive reactions contributing to the defensive behavior complex in wild rats appear to be regulated through 5HT 1A receptors. © 1992 Wiley‐Liss, Inc.