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Effects of serotonin receptor agonists and antagonists on offensive aggression in mice
Author(s) -
Lindgren Tone,
Kantak Kathleen M.
Publication year - 1987
Publication title -
aggressive behavior
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.223
H-Index - 92
eISSN - 1098-2337
pISSN - 0096-140X
DOI - 10.1002/1098-2337(1987)13:2<87::aid-ab2480130205>3.0.co;2-0
Subject(s) - quipazine , aggression , mianserin , serotonin , receptor , 5 ht receptor , stimulation , pharmacology , antagonist , endocrinology , medicine , chemistry , psychology , psychiatry
The effects of serotonin receptor agonists 5‐methoxytryptamine and quipazine, and antagonist mianserin on resident‐intruder offensive aggression were investigated. Both agonists reduced aggression. The fact that 5‐methoxytryptamine preferentially binds to 5‐HT‐1 receptors strongly suggest that the decreased aggression with S‐methoxytryptamine was related to stimulation of an inhibitory 5‐HT‐1 receptor. It is also suggested that the reduction in aggression with quipazine was related to quipazine's preferential binding to the 5‐HT‐1 receptor. The 5‐HT‐2 receptor antagonist mianserin reduced aggression suggesting that 5‐HT‐2 receptor blockade is inhibitory for aggression. Thus, two serotonin classes of receptors may be differentially involved in offensive aggression.