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Separate neural sites for d‐amphetamine suppression of mouse killing and feeding behavior in rats
Author(s) -
Yoshimura Hiroyuki,
Miczek Klaus A.
Publication year - 1983
Publication title -
aggressive behavior
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.223
H-Index - 92
eISSN - 1098-2337
pISSN - 0096-140X
DOI - 10.1002/1098-2337(1983)9:4<353::aid-ab2480090411>3.0.co;2-8
Subject(s) - amphetamine , nucleus accumbens , caudate nucleus , lateral hypothalamus , dextroamphetamine , medicine , endocrinology , hypothalamus , nucleus , chemistry , central nervous system , biology , neuroscience , dopamine
The present study was conducted to investigate several possible neural sites for d‐amphetamine's effect on mouse killing and feeding behaviors. d‐Amphetamine (10, 20, and 30 μg) injected into each lateral ventricle, suppressed mouse kiling, food, and water intake in a dose‐dependent manner. Bilateral adminstration of d‐amphetamine (20 μg) into the central amygdaloid nucleus abolished mouse killing behavior but did not affect feeding and drinking. By contrast, bilateral amphetamine injections into the substantia nigra, or into the ventral region of the caudate nucleus, did not suppress mouse killing behavior, but significantly decreased food and water intake. The lateral hypothalamus was sensitive to d‐amphetamine injections, which suppressed mouse killing and food intake as well as water intake. d‐Amphetamine injections into the nucleus accumbens produced inconsistent effects on mouse killing and feeding. Our observations suggest a differentiation of the neural sites that mediate feeding from those underlying mouse killing behavior.