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The influence of dibutyryl cyclic cmp on aggression in the mouse
Author(s) -
Benton David,
Newton Russell P.
Publication year - 1983
Publication title -
aggressive behavior
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.223
H-Index - 92
eISSN - 1098-2337
pISSN - 0096-140X
DOI - 10.1002/1098-2337(1983)9:4<281::aid-ab2480090402>3.0.co;2-c
Subject(s) - second messenger system , endocrinology , aggression , function (biology) , cyclic adenosine monophosphate , medicine , enzyme , nucleotide , cytidine , cyclic nucleotide , chemistry , biology , psychology , biochemistry , microbiology and biotechnology , receptor , gene , developmental psychology
Cytidine 3′,5′‐cyclic monophosphate (cCMP) and its associated enzymes have recently been identified in a number of mammalian tissues. The analogy with other cyclic nucleotides leads to speculation that it may prove to be a second messenger for some neurotransmitters and/or hormones. In this study we examined the possibility that cCMP may modulate aggressive behaviour. When dibutyryl cCMP (250 μg and 2.5 mg/k SC) was administered to mice it proved to have a potent antiaggressive influence but had little effect on general activity. It was concluded that cCMP may prove to have an important metabolic function.