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Ethological analysis of neuropeptides and psychotropic drugs: Effects on intraspecies aggression and sociability of isolated mice
Author(s) -
Poshivalov Vladimir P.
Publication year - 1982
Publication title -
aggressive behavior
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.223
H-Index - 92
eISSN - 1098-2337
pISSN - 0096-140X
DOI - 10.1002/1098-2337(1982)8:4<355::aid-ab2480080404>3.0.co;2-3
Subject(s) - aggression , haloperidol , diazepam , agonistic behaviour , neuropeptide , somatostatin , muscimol , psychology , pharmacology , psychotropic agent , medicine , gabaa receptor , neuroscience , psychiatry , receptor , dopamine
The experiments on mice (under the condition of agonistic interactions) have shown increases and decreases in certain forms of species‐specific behavior (aggression, defense, sociability) when synthetic peptides and psychotropic drugs were administered. MIF‐1, TRH, and LH‐RH (acute injections) enhance aggression in isolated mice while somatostatin reduces it. MIF–1 antagonizes the antiaggressive effects of haloperidol, muscimol, and morphine. ACTH 1–24 counteracts the action of diaze‐pam on attacks and threats. Somatostatin reduces both aggression and sociability and that effect may be potentiated by diazepam. Neo‐endorphin injected together with diazepam reduces aggression and enhances sociability. A combination of synthetic neuropeptides and well known psychotropic drugs (neuroleptics, tranquil‐izers, and others) may be more effective for the control of aggression and sociability than the psychotropic drugs employed alone.