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Directional interaction of midbrain and hypothalamus in the control of carbachol‐induced aggression
Author(s) -
Stokman Cornelis L. J.,
Glusman Murray
Publication year - 1981
Publication title -
aggressive behavior
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.223
H-Index - 92
eISSN - 1098-2337
pISSN - 0096-140X
DOI - 10.1002/1098-2337(1981)7:2<131::aid-ab2480070206>3.0.co;2-1
Subject(s) - carbachol , midbrain , atropine , hypothalamus , aggression , microinjection , endocrinology , lateral hypothalamus , medicine , psychology , neuroscience , periaqueductal gray , central nervous system , developmental psychology , stimulation
Microinjection of carbachol into the ventromedial part of the anterior hypothalamus or the ventrolateral part of the mesencephalic central gray elicits affective aggression in the cat. Pretreatment with atropine in the same site blocks carbachol‐induced aggression. Prior administration of atropine into the midbrain blocks aggression induced by carbachol injections into the hypothalamus, but atropine injected into the hypothalamus does not prevent affective aggression elicited by carbachol administered into the midbrain. The results demonstrate a directional interaction between midbrain and hypothalamus, and provide suggestive evidence for a hierarchal organization of these limbic structures in the control of cholinergically‐mediated affective aggression.