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Effects of neonatal cyproterone acetate administration on isolation‐induced fighting behavior and mounting behavior in male and female TO strain albino mice
Author(s) -
Poole Angela E.,
Brain Paul F.
Publication year - 1975
Publication title -
aggressive behavior
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.223
H-Index - 92
eISSN - 1098-2337
pISSN - 0096-140X
DOI - 10.1002/1098-2337(1975)1:2<165::aid-ab2480010206>3.0.co;2-b
Subject(s) - cyproterone acetate , testosterone propionate , castration , endocrinology , medicine , cyproterone , endocrine system , testosterone (patch) , antiandrogen , androgen , psychology , physiology , hormone
The effects of a single dose (1 mg) of cyproterone acetate administered on either day 1 or day 20 of life on the adult behaviors of male and female TO strain albino mice were studied. The mice were tested both in a “standard opponent”‐type situation and in a similar test using a hormonally primed receptive female, after being gonadectomized and maintained with testosterone propionate as adults. Neonatal treatment with this compound had little effect on subsequent fighting behavior in either sex, but clear evidence was produced that this treatment masculinized the sexual behavioral potentialities of the females, an effect which was apparent in animals which had been injected on either day 1 or day 20 of life. Indications were obtained that females treated neonatally with cyproterone acetate were capable of differentiating between the male and female “opponents” in a manner similar to the male. The effects of this treatment on fighting behavior consequently appear to be dissimilar to the effects of neonatal castration in this species. However, the effects on mounting behavior in the females, evidenced in adulthood, seem Likely to be a consequence of the weak androgenic properties of the antiandrogen. The administration of cyproterone acetate neonatally appears to have a more dramatic effect on the adult weights of endocrine organs in females than in mates.