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Tributyltin induces cytogenetic damage in the early life stages of the marine mussel, Mytilus edulis
Author(s) -
Jha Awadhesh N.,
Hagger Josephine A.,
Hill Stephen J.
Publication year - 2000
Publication title -
environmental and molecular mutagenesis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1
H-Index - 87
eISSN - 1098-2280
pISSN - 0893-6692
DOI - 10.1002/1098-2280(2000)35:4<343::aid-em9>3.0.co;2-5
Subject(s) - mytilus , tributyltin , biology , marine invertebrates , invertebrate , mussel , blue mussel , genotoxicity , sister chromatid exchange , zoology , toxicology , toxicity , ecology , genetics , chemistry , dna , organic chemistry
Using an integrated approach, the genotoxic potential of bis(tri‐n‐butyltin), an antifouling agent known to disrupt endocrine system in marine invertebrates, has been evaluated in the embryo‐larval stages of the edible mussel, Mytilus edulis . While evaluating the genotoxic potential, the toxicity of tributyltin was also taken into account by determining the maximum tolerated dose. The study suggested that tributyltin is capable of inducing cytogenetic damage (sister chromatid exchanges and chromosomal aberrations) in this target species. The study emphasises the need for further investigations of the potential genotoxic effects of this and other endocrine disrupters on ecologically relevant aquatic invertebrates, which contribute to the maintenance of ecosystems and that could potentially be harmful to human health via the food chain. Environ. Mol. Mutagen. 35:343–350, 2000 © 2000 Wiley‐Liss, Inc.