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A weighted test using both extreme discordant and concordant sib pairs for detecting linkage
Author(s) -
Li Zhaohai,
Gastwirth Joseph L.
Publication year - 2001
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/1098-2272(200101)20:1<34::aid-gepi4>3.0.co;2-k
Subject(s) - linkage (software) , statistics , trait , statistical power , biology , quantitative trait locus , genetics , genetic linkage , statistical hypothesis testing , computational biology , mathematics , computer science , gene , programming language
Statistical procedures using extremely discordant and concordant sib‐pairs have been developed for mapping quantitative trait loci in humans. To improve the power of the existing methods, test statistics placing greater weight on the more discordant or more concordant pairs are proposed. Because the optimum choice of weights would depend on the underlying genetic model, which is not usually known, a test with simple weights is suggested. This test is shown to have greater power than the currently available ones for a variety of genetic models. Genet. Epidemiol. 20:34–43, 2001. © 2001 Wiley‐Liss, Inc.