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Use of classification trees for association studies
Author(s) -
Zhang Heping,
Bonney George
Publication year - 2000
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/1098-2272(200012)19:4<323::aid-gepi4>3.0.co;2-5
Subject(s) - warrant , genetic association , tree (set theory) , association (psychology) , decision tree , computer science , computational biology , statistics , machine learning , biology , mathematics , genetics , psychology , combinatorics , single nucleotide polymorphism , genotype , financial economics , economics , psychotherapist , gene
We propose the use of classification trees for association studies. This approach is applied to a data set from Genetic Analysis Workshop 9 (GAW9), and our analysis precisely identified two disease alleles. Our purpose is to demonstrate the great potential of tree‐based analyses for genetic studies, and discuss some issues that warrant further investigation. Genet. Epidemiol. 19:323–332, 2000. © 2000 Wiley‐Liss, Inc.