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Power of a score test for quantitative trait linkage analysis of relative pairs
Author(s) -
Goldstein Darlene R.,
Dudoit Sandrine,
Speed Terence P.
Publication year - 2000
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/1098-2272(2000)19:1+<::aid-gepi13>3.0.co;2-7
Subject(s) - identity by descent , heritability , statistics , quantitative trait locus , score test , trait , genetics , mathematics , biology , allele , likelihood ratio test , computer science , haplotype , gene , programming language
The score test of Dudoit and Speed [(2000) Biostatistics 1:1–26] to detect linkage between a trait locus and a marker locus, using identity by descent data on sib pairs, is extended to other types of relative pairs (grandparent/grandchild, avuncular, and half‐sib relationships). The test is based on the likelihood of the recombination fraction θ between trait and marker loci, conditional on phenotypes of the relatives. We present results of simulation studies characterizing power and robustness properties of this linkage score test, and compare the power of the score test to that of the classical and modified Haseman‐Elston tests. The score test has considerable power, particularly under sampling schemes where selection is on double probands. Use of a generic additive model [Goldstein et al., submitted] with allele frequency p = 0.2, heritability H = 0.3, and a moderate residual correlation of ρ = 0.2 resulted in a very good overall performance across a wide range of trait‐generating models. Genet. Epidemiol. 19(Suppl 1):S85–S91, 2000. © 2000 Wiley‐Liss, Inc.