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RIZ , the retinoblastoma protein interacting zinc finger gene, is mutated in genetically unstable cancers of the pancreas, stomach, and colorectum
Author(s) -
Sakurada Kaori,
Furukawa Toru,
Kato Yo,
Kayama Takamasa,
Huang Shi,
Horii Akira
Publication year - 2001
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/1098-2264(2000)9999:9999<::aid-gcc1080>3.0.co;2-v
Subject(s) - frameshift mutation , biology , retinoblastoma , gene , zinc finger , microsatellite instability , cancer research , coding region , carcinogenesis , pancreas , mutation , tumor suppressor gene , genetics , microsatellite , transcription factor , allele , biochemistry
The retinoblastoma protein interacting zinc finger ( RIZ ) gene is a candidate tumor suppressor gene on 1p36, a region frequently rearranged in a wide variety of human tumors. As the RIZ gene harbors several microsatellites within its coding region, it is a candidate for an inactivating mutation in microsatellite instability (MSI) mediated carcinogenesis. In this study, we examined mutations of two poly adenine tracts, A 8 and A 9 , within the coding region of the RIZ gene, in MSI‐high (MSI‐H) primary cancers occurring in the pancreas, stomach, and colorectum. Frameshift mutations were found in one (10%) of 10 pancreatic, four (36%) of 11 gastric, and two (25%) of eight colorectal cancers. These results indicate that mutations of the RIZ gene play an important role in the pathogenesis of some MSI‐H cancers. © 2000 Wiley‐Liss, Inc.