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Gene BRI40, Which is Related to AF1O and AF17, Maps to Chromosome Band 3p25
Author(s) -
Sahin Feride I.,
Lillington Debra M.,
Meerabux Joanne,
Saha Vaskar,
McCullagh Paul,
Young Bryan D.,
Gregorini Armando,
Bocci Maura,
Papa Stefano,
Menevse Sevda
Publication year - 1996
Publication title -
genes, chromosomes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.754
H-Index - 119
eISSN - 1098-2264
pISSN - 1045-2257
DOI - 10.1002/1098-2264(199612)17:4<269::aid-gcc2870170402>3.0.co;2-a
Subject(s) - leucine zipper , zinc finger , gene , biology , chromosomal translocation , homology (biology) , genetics , chromosome , chromosome band , ring finger domain , fluorescence in situ hybridization , bzip domain , lim domain , microbiology and biotechnology , transcription factor
The genes AF10 and AF1 7 have been identified as the basis of the t( 10;11) and t( I I; 17) translocations, events that result in their fusion to the MLUHRX gene in acute myeloid leukaemias. AFlO and AF17 bear significant homology to each other within their putative zinc finger and leucine zipper domains, although they are diverged outside these regions. The 6R140 gene encodes a 140 kDa protein of unknown function that contains a putative zinc finger domain, a leucine zipper region, and, in addition, a bromo domain. The zinc finger and leucine zipper domains of 6Rl40 have significant homology to those of AFlO and AF17, suggesting that it belongs to this newly described gene family and, therefore, could be a target for chromosome translocation. To assess the potential involvement of BR140 in chromosome translocations in leukaemia, the chromosomal location of the BRl40 gene has been determined by using several independent methods. A combination of Southern analysis, polymerase chain reactions (PCR) on monochromosomal cell hybrids, and fluorescence in situ hybridisation (FISH) has been used to show that the 6R140 gene maps to chromosome band 3p25. Genes Chrornosorn Cancer 17:269–272 (l996). © 1996 Wiley‐Liss, Inc.