Premium
Somatostatin in eating disorders
Author(s) -
Pirke Karl M.,
Frieß Elisabeth,
Kellner Michael B.,
Krieg JürgenC.,
Fichter Manfred M.
Publication year - 1994
Publication title -
international journal of eating disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.785
H-Index - 138
eISSN - 1098-108X
pISSN - 0276-3478
DOI - 10.1002/1098-108x(199401)15:1<99::aid-eat2260150112>3.0.co;2-x
Subject(s) - anorectic , somatostatin , medicine , endocrinology , anorexia nervosa , meal , eating disorders , gastric emptying , hormone , growth hormone , anorexia , body weight , psychology , stomach , psychiatry
Somatostatin concentrations in plasma were measured before and after a standardized fat and protein‐rich fluid test meal in patients with anorexia nervosa, weight‐recovered anorectic patients, obese women, and healthy controls. Somatostatin was significantly elevated in all four groups after the test meals. Hormone levels remained elevated for up to 100 min after the test meal. The area under the response curve was significantly higher (p < .01) in the anorectic patients as compared with healthy controls and weight‐recovered anorectics. Obese women had blunted somatostatin responses. The findings may explain alterations in insulin secretion and in gastric emptying described earlier in patients with eating disorders. © 1994 by John Wiley & Sons, Inc.