Premium
Activity‐induced anorexia in rats does not affect hypothalamic neuropeptide gene expression chronically
Author(s) -
Wong MaLi,
Licinio Júlio,
Gold Philip W.,
Glowa John
Publication year - 1993
Publication title -
international journal of eating disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.785
H-Index - 138
eISSN - 1098-108X
pISSN - 0276-3478
DOI - 10.1002/1098-108x(199305)13:4<399::aid-eat2260130408>3.0.co;2-j
Subject(s) - neuropeptide , endocrinology , medicine , anorexia , vasopressin , neuropeptide y receptor , corticosterone , hormone , appetite , eating disorders , adrenocorticotropic hormone , hypothalamus , psychology , pathophysiology , biology , receptor , psychiatry
Hypothalamic neuropeptides are thought to contribute to the pathophysiology of eating disorders. In an animal model with chronic abnormalities of energy expenditure, appetitive behavior, and body weight, without acute food restriction, we found alterations in peripheral levels of adrenocorticotropic hormone and corticosterone, but no alterations in the expression of neuropeptides genes that are known to regulate ingestive behavior and food intake acutely. Our data suggest that activation of hypothalamic‐pituitary‐adrenal function in activity anorexia may not be due to increased transcription of corticotropin‐releasing hormone gene, but might be related to posttranscriptional events or to other neuropeptides, such as arginine vasopressin. Furthermore, we suggest that abnormalities in neuropeptides observed in eating disorders may be caused by acute food restriction, rather than by chronic hyper‐activity, anorexia, and low weight. © 7 1993 by John Wiley & Sons, Inc.