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A controlled family study of anorexia nervosa: Evidence of familial aggregation and lack of shared transmission with affective disorders
Author(s) -
Strober Michael,
Lampert Carolyn,
Morrell Wendy,
Burroughs Jane,
Jacobs Carrie
Publication year - 1990
Publication title -
international journal of eating disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.785
H-Index - 138
eISSN - 1098-108X
pISSN - 0276-3478
DOI - 10.1002/1098-108x(199005)9:3<239::aid-eat2260090302>3.0.co;2-7
Subject(s) - anorexia nervosa , proband , psychology , eating disorders , psychiatry , depression (economics) , anorexia , comorbidity , clinical psychology , medicine , genetics , mutation , macroeconomics , biology , economics , gene
Lifetime prevalence rates of eating disorders and affective disorder were determined in biological relatives of probands with anorexia nervosa, affective disorder, and other types of psychiatric disturbance. Anorexia nervosa was found to cluster in families with intergenerational transmission, and was absent among relatives of controls. Significantly higher rates of affective disorder were found among relatives of anorexics with coexisting depression, suggesting that these probands transmit two disorders to relatives. The results indicate there is familial resemblance for anorexia nervosa, and that the liability is different from that operating in the transmission of affective disorders.