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The prolactin, growth hormone, and cortisol responses to insulin‐induced hypoglycemia in anorexia nervosa
Author(s) -
Nakai Yoshikatsu,
Koh Toshikiyo,
Kinoshita Fumiko,
Tsujii Satoru,
Tsukada Toshihiko,
Imura Hiroo,
Note Shinya
Publication year - 1987
Publication title -
international journal of eating disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.785
H-Index - 138
eISSN - 1098-108X
pISSN - 0276-3478
DOI - 10.1002/1098-108x(198705)6:3<357::aid-eat2260060305>3.0.co;2-1
Subject(s) - medicine , endocrinology , anorectic , hypoglycemia , prolactin , anorexia nervosa , insulin , thyrotropin releasing hormone , basal (medicine) , hormone , hydrocortisone , stimulation , body weight , eating disorders , psychiatry
Plasma levels of prolactin and their response to insulin‐induced hypoglycemia or to the thyrotropin‐releasing hormone (TRH) were measure in 17 females with primary anorexia nervosa when they were 54.9‐73.2% of ideal body weight (IBW) (group 1) and in 15 cases during or after weight gain (75.1‐100.4% of IBW, group 2). Basal prolactin concentrations were well within the normal range (less than 25 ng/ml) in all anorectic patients except in one patient who had a value of 42.3 ng/ml. Prolactin response to insulin‐induced hypoglycemia was markedly impaired or absent in 16 out of the patients in Group 1 but improved dramatically in 9 of the patients in Group 2. Direct stimulation of the pituitary with TRH, however, produced a prolactin release in all anorectic patients studied. Plasma GH response to insulin‐induced hypoglycemia was impaired in 12 of the patients in group 1 and 12 of the patients in group 2. Plasma cortisol response to insulin‐induced hypoglycemia was impaired in 11 of the patients in group 1 and in 3 of the patients in group 2. These findings indicate that the hypothalamic function in anorectic patients is altered.