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Abnormal plasma carnitine derivatives reflecting an altered metabolic state in anorexic women at rest and following maximal effort treadmill exercise
Author(s) -
Len Doris L. F.,
Einerson Jean A.,
Hanson Peter G.,
Nagle Francis J.
Publication year - 1987
Publication title -
international journal of eating disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.785
H-Index - 138
eISSN - 1098-108X
pISSN - 0276-3478
DOI - 10.1002/1098-108x(198703)6:2<281::aid-eat2260060211>3.0.co;2-g
Subject(s) - medicine , endocrinology , long chain , carnitine , chemistry , treadmill , anorexia nervosa , psychiatry , polymer science , eating disorders
Five women diagnosed as having classical anorexia nervosa were studied at rest and following a maximal effort treadmill test prior to (AN‐1) and after hospital treatment (AN‐II). A group of 14 lean women (matched for age, percent body fat, height, weight, and fitness level as closely as possible) were studied as lean controls (LC). Before treatment, AN‐I had significantly less plasma long‐chain acyl carnitines than LC (4.59 versus 6.16 μM), whereas short‐chain acyl carnitines were nearly twice as high (9. 01 versus 4. 91 μM, AN‐1 versus LC) at rest. Following maximal exercise LC women demonstrated a sharp increase in short‐chain acyl carnitines (from 4. 19 to 8. 83 μM), whereas the AN‐1 group showed no change in these derivaties relative to their resting level (from 9.01 to 10. 49 μM). Long‐chain acyl carnitines, however, were reduced in AN‐1 compared with LC after exercise (2.37 versus 6.55 μM, respectively). Following hospital treatment short‐chain acyl carnitines at rest were reduced toward normal (6.68 μM) in the AN‐II, although the long‐chain acyl forms still remained lower (3.2 1 μM) than in the LC (6.16 μM). However, even aiter hospital treatment the AN‐II group did not show the typical increase in short‐chain acyl carnitines with an acute bout oi exercise.