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Perception of hunger and satiety induced by 2‐deoxy‐D‐glucose in anorexia nervosa and bulimia nervosa
Author(s) -
Nakai Yoshikatsu,
Kinoshita Fumiko,
Koh Toshikiyo,
Tsujii Satour,
Tsukada Toshihiko
Publication year - 1987
Publication title -
international journal of eating disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.785
H-Index - 138
eISSN - 1098-108X
pISSN - 0276-3478
DOI - 10.1002/1098-108x(198701)6:1<49::aid-eat2260060107>3.0.co;2-r
Subject(s) - anorexia nervosa , bulimia nervosa , ingestion , endocrinology , medicine , psychology , anorexia , food intake , eating disorders , psychiatry
The effect of intracellular glucopenia induced by 2‐deoxy‐D‐glucose (2‐DG) on changes in hunger ratings, blood glucose, plasms cortisol, and prolactin levels were examined in six female patients with primary anorexia nervosa, three patients with bulimia nervosa, and six age‐and sex‐matched volunteers. In the normal subjects, hunger ratings obtained by the linear visual analog technique increased significantly at 60 minutes after 2‐DG infusion and remained elevated. In Patients with anorexia nervosa, however, hunger ratins paradoxically decreased significantly at 90 minutes. In normal subjects, the ingestion of a 20‐minute lunch relieved hunger, but neither the anorexic patients nor bulimic patients felt satiety even after food intake. These results suggest that the perception of hunger induced by 2‐DG in anorexia nervosa and that of satiety in anorexia nervosa and bulimia nervosa are disturbed.