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Noradrenaline, trijodthyronine, growth hormone and prolactin during weight gain inanorexia nervosa
Author(s) -
Pirke Karl M.,
Fichter Manfred M.,
Pahl Jorg
Publication year - 1985
Publication title -
international journal of eating disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.785
H-Index - 138
eISSN - 1098-108X
pISSN - 0276-3478
DOI - 10.1002/1098-108x(198511)4:4<499::aid-eat2260040410>3.0.co;2-7
Subject(s) - anorexia nervosa , prolactin , supine position , endocrinology , medicine , growth hormone , weight gain , body weight , morning , hormone , eating disorders , psychiatry
Thirteen patients with anorexia nervosa, aged 16–23 years (2 males and 11 females), were studied during the first week after hospital admission at an average weight of 65.4±6.2% of ideal body weight (IBW), again after a weight increase of 10%, and before discharge. The patients gained weight in a broad spectrum behavior therapy program. Serial blood samples were obtained during the morning hours. Growth hormone was greatly elevated in about half of the patients during the first study. After 10% weight gain, values were normalized and stayed unchanged thereafter. Trijodthyronine values were low in the beginning. The values were significantly increased at the second assessment but continued to rise thereafter. Noradrenaline concentrations in plasma were normal at the first assessment, as well as in both a supine and in an erect body position. After 10% weight gain, resting levels were significantly decreased and the increase while standing was impaired. At the last assessment, at an average body weight of 80.9± 7% IBW, noradrenaline levels were greater than at the second assessment, but not yet normalized. Plasma prolactin remained unchanged during the entire study.