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Hypothalamic regulation of gonadotropin secretion in anorexia nervosa and in starvation
Author(s) -
Pirke K. M.,
Fichter M. M.,
Warnhoff M.,
Dorsch G.,
Spyra B.
Publication year - 1983
Publication title -
international journal of eating disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.785
H-Index - 138
eISSN - 1098-108X
pISSN - 0276-3478
DOI - 10.1002/1098-108x(198322)2:4<151::aid-eat2260020423>3.0.co;2-q
Subject(s) - endocrinology , medicine , anorexia nervosa , dynorphin , gonadotropin , median eminence , dopamine , secretion , hypothalamus , hormone , gonadotropin releasing hormone , psychology , eating disorders , luteinizing hormone , psychiatry , opioid peptide , opioid , receptor
The regulation of gonadotropin secretion was studied in anorexia nervosa, in voluntarily starving healthy subjects, and in the starved rat. In all cases, a hypothalamic disturbance is observed, resulting in an impaired ability to secrete gonadotropin‐releasing hormone (CnRH) from the median eminence. This effect is weight‐dependent in man and animals. The central neurotransmitters noradrenaline, dopamine, dynorphin, and prostaglandin E 2 are involved in the regulation of GnRH release. A decreased activity of the catecholaminergk system and an increased activity of the endorphinergic system may be responsible for the impaired GnRH release.