Open AccessSynthesis of quinazolines using carbon dioxide (or carbon monoxide with sulfur) under mild conditions
Author(s) -
Mizuno Takumi,
Okamoto Noriaki,
Ito Takatoshi,
Miyata Toshiyuki
Publication year - 2000
Publication title -
heteroatom chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.283
H-Index - 42
eISSN - 1098-1071
pISSN - 1042-7163
DOI - 10.1002/1098-1071(2000)11:6<428::aid-hc12>3.0.co;2-z
Subject(s) - chemistry , heteroatom , carbon monoxide , carbonylation , carbon dioxide , sulfur , sulfur dioxide , compounds of carbon , electrochemical reduction of carbon dioxide , carbon fixation , organic chemistry , carbon fibers , inorganic chemistry , chemical reaction , catalysis , ring (chemistry) , materials science , composite number , composite material
Sulfur‐assisted carbonylation of 2‐aminobenzonitriles with carbon monoxide using K 2 CO 3 as a base under ambient conditions (1 atm, 20°C) to afford 2‐hydroxy‐4‐mercaptoquinazolines in excellent yields was found. This carbonylation was applied to chemical fixation of carbon dioxide under mild conditions. Carbon dioxide (1 atm) easily reacted with 2‐aminobenzonitriles at 20°C assisted by 1,8‐diazabicyclo[5.4.0]undec‐7‐ene (DBU) to give 2,4‐dihydroxyquinazolines in excellent yields. © 2000 John Wiley & Sons, Inc. Heteroatom Chem 11:428–433, 2000