Open AccessSynthesis and structure of novel phosphonodipeptides containing a uracil or thymine group
Author(s) -
Liu XueJun,
Chen RuYu,
Weng LinHong,
Leng XueBing
Publication year - 2000
Publication title -
heteroatom chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.283
H-Index - 42
eISSN - 1098-1071
pISSN - 1042-7163
DOI - 10.1002/1098-1071(2000)11:6<422::aid-hc11>3.0.co;2-j
Subject(s) - chemistry , uracil , heteroatom , thymine , group (periodic table) , crystal structure , crystallography , coupling reaction , proton nmr , stereochemistry , protecting group , organic chemistry , catalysis , dna , ring (chemistry) , biochemistry , alkyl
A series of novel phosphonodipeptides containing a uracil or thymine group was synthesized in 54.2–74.1% yields by means of a peptide coupling reaction with DCC as the dehydrating agent and 1‐hydroxybezotriazole as the activating agent of the carboxyl group. All products were characterized by 1 H NMR, 31 P NMR and IR spectra, and by elemental analyses. The crystal and molecular structure of compound 6c has been determined by X‐ray diffraction. © 2000 John Wiley & Sons, Inc. Heteroatom Chem 11:422–427, 2000