Premium
Effects of behavioral stimuli on plasma interleukin‐1 activity in humans at rest
Author(s) -
Keppel William H.,
Regan David H.,
Heffeneider Steven H.,
McCoy Sharon,
Ramsey Fred
Publication year - 1993
Publication title -
journal of clinical psychology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.124
H-Index - 119
eISSN - 1097-4679
pISSN - 0021-9762
DOI - 10.1002/1097-4679(199311)49:6<777::aid-jclp2270490605>3.0.co;2-2
Subject(s) - stimulus (psychology) , psychology , immune system , interleukin 1β , medicine , interleukin , endocrinology , cytokine , developmental psychology , immunology , psychotherapist
Interleukin‐1 (IL‐1) bioassays were done on 208 serum samples drawn from 7 volunteers, over several hours at 5‐minute intervals, before, during, and after a relaxation‐related behavioral stimulus. Individuals showed up to a 267% increase ( t [29] = 7.750, p = 1 × 10 −7 .) in IL‐1, and for the group, a mean 48.1% elevation ( t [5] = 4.128, p =.003) occurred, during the stimulus interval relative to baseline. When baselines were repeated, IL‐1 activity rapidly returned toward baseline values. Suggestions to picture one's immune cells fighting illness appeared to have no uniform effect for all subjects. Such rapid changes in plasma IL‐1, concomitant with stimuli, indicate a new way to alter immune function and further understand disease susceptibility.