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Ubiquitin‐mediated proteolysis of vertebrate G1‐ and S‐phase regulators
Author(s) -
Yew P. Renee
Publication year - 2001
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/1097-4652(2001)9999:9999<1::aid-jcp1049>3.0.co;2-o
Subject(s) - proteolysis , ubiquitin , vertebrate , microbiology and biotechnology , biology , chemistry , biochemistry , enzyme , gene
Cell‐cycle progression in all eukaryotes is driven by cyclin‐dependent kinases (CDKs) and their cyclin partners. In vertebrates, the proper and timely duplication of the genome during S‐phase relies on the coordinated activities of positive regulators such as CDK–cyclins and E2F, and negative regulators such as CDK inhibitors of the Cip/Kip and INK4 families. Recent and ongoing work indicates that many important regulators of G1‐ and S‐phases are targeted for ubiquitination and subsequent degradation by the 26S proteasome. The proteolysis of key proteins during G1‐ and S‐phases appears to be central for proper custodial regulation of DNA replication and the maintenance of cellular homeostasis in general. This review highlights the current literature regarding ubiquitin‐mediated proteolysis of G1‐ and S‐phase regulators and the control of events during the initiation and completion of DNA replication in vertebrates. © 2000 Wiley‐Liss, Inc.