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Potent inhibitory action of red wine polyphenols on human breast cancer cells
Author(s) -
Damianaki Athina,
Bakogeorgou Efstathia,
Kampa Marilenna,
Notas George,
Hatzoglou Anastassia,
Panagiotou Simone,
Gemetzi Claudia,
Kouroumalis Elias,
Martin PierreMarie,
Castanas Elias
Publication year - 2000
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/1097-4644(20000901)78:3<429::aid-jcb8>3.0.co;2-m
Subject(s) - polyphenol , wine , chemistry , antioxidant , resveratrol , white wine , pharmacology , in vivo , apoptosis , cell growth , quercetin , biochemistry , biology , food science , microbiology and biotechnology
Breast cancer (one of the most common malignancy in Western societies), as well as esophagus, stomach, lung, bladder, and prostate cancer, depend on environmental factors and diet for growth and evolution. Dietary micronutriments have been proposed as effective inhibitory agents for cancer initiation, progression, and incidence. Among them, polyphenols, present in different foods and beverages, have retained attention in recent years. Red wine is a rich source of polyphenols, and their antioxidant and tumor arresting effects have been demonstrated in different in vitro and in vivo systems. In the present study, we have measured the antiproliferative effect of red wine concentrate, its total polyphenolic pool, and purified catechin, epicatechin, quercetin, and resveratrol, which account for more than 70% of the total polyphenols in red wine, on the proliferation of hormone sensitive (MCF7, T47D) and resistant (MDA‐MB‐231) breast cancer cell lines. Our results indicate that polyphenols, at the picomolar or the nanomolar range, decrease cell proliferation in a dose‐ and a time‐dependant manner. In hormone sensitive cell lines, a specific interaction of each polyphenol with steroid receptors was observed, with IC 50 s lower than previously described. Interaction of polyphenols with steroid receptors cannot fully explain their inhibitory effect on cell proliferation. In addition, discrete antioxidant action on each cell line was detected under the same concentrations, both by modifying the toxic effect of H 2 O 2 , and the production of reactive oxygen species (ROS), after phorbol ester stimulation. Our results suggest that low concentrations of polyphenols, and consecutively, consumption of wine, or other polyphenol‐rich foods and beverages, could have a beneficial antiproliferative effect on breast cancer cell growth. J. Cell. Biochem. 78:429–441, 2000. © 2000 Wiley‐Liss, Inc.