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Processing and hydrolytic degradation of aromatic, ortho ‐substituted polyanhydrides
Author(s) -
Bedell Christi,
Deng Meng,
Anastasiou Theodore J.,
Uhrich Kathryn E.
Publication year - 2001
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/1097-4628(20010404)80:1<32::aid-app1071>3.0.co;2-9
Subject(s) - polymer , materials science , compression molding , chemical engineering , polymer chemistry , hydrolysis , solvent , degradation (telecommunications) , polymer degradation , solubility , hydrolytic degradation , casting , chemistry , composite material , organic chemistry , mold , telecommunications , computer science , engineering
Polyanhydrides containing 1,3‐bis( p ‐carboxyphenoxy)propane, abbreviated poly( p ‐CPP), are currently being used as controlled‐release devices for the treatment of brain cancer. These polymers are biodegradable and biocompatible and release pharmaceuticals in a controlled fashion. However, polyanhydrides have an important drawback: The polymers themselves are highly insoluble in both organic solvents and water and have high melting temperatures, rendering them difficult to process into fibers and/or films. Previously, we synthesized polymers that overcame the solubility and, thus, processing problems associated with poly( p ‐CPP). In this report, we describe the mechanical properties and hydrolytic degradation characteristics of these newly developed polyanhydrides. After formation of films by either compression‐molding or solvent‐casting, the polymer surfaces were examined by SEM. Mechanical studies were also performed on the compression‐molded samples. Compression‐molded samples were sterilized by γ‐irradiation and then examined by GPC for changes in their polymer structure. Lastly, the polymers and the degradation media were evaluated by TGA, DSC, GPC, and HPLC to gain a better understanding of the degradation process. © 2001 John Wiley & Sons, Inc. J Appl Polym Sci 80: 32–38, 2001