Premium
Imprinted polymers prepared by aqueous suspension polymerization
Author(s) -
Flores Asier,
Cunliffe David,
Whitcombe Michael J.,
Vulfson Evgeny N.
Publication year - 2000
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/1097-4628(20000822)77:8<1841::aid-app22>3.0.co;2-p
Subject(s) - aqueous suspension , polymer , aqueous solution , suspension polymerization , suspension (topology) , polymerization , materials science , chemical engineering , polymer chemistry , polymer science , chemistry , organic chemistry , composite material , engineering , mathematics , homotopy , pure mathematics
The feasibility of preparing cholesterol‐imprinted polymers by aqueous suspension polymerization was investigated by the preparation of ethyleneglycol dimethacrylate and divinylbenzene‐based beads imprinted using cholesteryl(4‐vinyl)phenyl carbonate as the template. A low volatility porogen to replace a 4:1 hexane/toluene mixture was selected on the basis of solubility parameters and consisted of dioctyl phthalate/ n ‐decane 77:23 v/v. Beads were prepared using a range of porogen contents with the best results obtained at 5.5–6.5 mL /5 g of monomer. Uptake of cholesterol by suspension polymers was broadly similar to that of the corresponding “bulk” polymers, but suffered from higher nonspecific binding. © 2000 John Wiley & Sons, Inc. J Appl Polym Sci 77: 1841–1850, 2000