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Thermoreversible hydrogels X: Synthesis and swelling behavior of the ( N ‐isopropylacrylamide‐ co ‐sodium 2‐acrylamido‐2‐methylpropyl sulfonate) copolymeric hydrogels
Author(s) -
Lee WenFu,
Yuan WenYang
Publication year - 2000
Publication title -
journal of applied polymer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.575
H-Index - 166
eISSN - 1097-4628
pISSN - 0021-8995
DOI - 10.1002/1097-4628(20000822)77:8<1760::aid-app13>3.0.co;2-j
Subject(s) - self healing hydrogels , swelling , counterion , sulfonate , poly(n isopropylacrylamide) , polymer chemistry , monomer , sodium , copolymer , chemistry , chemical engineering , polyelectrolyte , materials science , polymer , organic chemistry , composite material , ion , engineering
A series of thermosensitive hydrogels were prepared from various molar ratios of N ‐isopropylacrylamide (NIPAAm) and sodium‐2‐acrylamido‐2‐methylpropyl sulfonate (NaAMPS). Factors such as temperature and initial total monomer concentration and different pH solutions were investigated. Results indicated that the more the NaAMPS content in hydrogel system, the higher the swelling ratio and the gel transition temperature; the higher the initial monomer concentration, the lower the swelling ratio. The result also indicated that the NIPAAm/NaAMPS copolymeric hydrogels had different swelling ratios in various pH environments. The present gels showed a pH‐reversible property between pH 3 and pH 10 and thermoreversibility. The swelling ratios of copolymeric gels were lower in a strong alkaline environment because the gels were screened by counterions. Finally, the drug release behavior of these gels was also investigated in this article. © 2000 John Wiley & Sons, Inc. J Appl Polym Sci 77: 1760–1768, 2000