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Coagulation and fibrinolysis disorder in muscular dystrophy
Author(s) -
Saito Toshio,
Takenaka Marina,
Miyai Ichiro,
Yamamoto Yuko,
Matsumura Tsuyoshi,
Nozaki Sonoko,
Kang Jin
Publication year - 2001
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/1097-4598(200103)24:3<399::aid-mus1012>3.0.co;2-b
Subject(s) - muscular dystrophy , medicine , fibrinolysis , duchenne muscular dystrophy , fibrinogen , spinal muscular atrophy , creatine kinase , fibrin , myotonic dystrophy , endocrinology , facioscapulohumeral muscular dystrophy , d dimer , immunology , disease
To investigate whether there are any basic abnormalities of coagulation and fibrinolysis in muscular dystrophy, we measured serum levels of the MM isozyme of creatine kinase (CK‐MM), fibrin and fibrinogen degradation products (FDP), plasma levels of fibrinogen, antithrombin (AT), and D‐dimer in 36 patients with Duchenne muscular dystrophy (DMD), 11 with Becker muscular dystrophy (BMD), 5 with Fukuyama congenital muscular dystrophy (FCMD), 5 with myotonic dystrophy (MyD), and 5 with spinal muscular atrophy (SMA) type 2. FDP levels were elevated in the patients with DMD, BMD, and FCMD (1.0 to 84.9 μg/ml), but not in the patients with MyD and SMA type 2. In DMD, BMD, and FCMD, FDP levels significantly correlated with CK‐MM, but not with age, fibrinogen, AT, D‐dimer, and type of dystrophy (multiple regression analysis; r 2 = 0.814, P < 0.0001). These findings suggested that enhanced coagulation and fibrinolysis are associated with muscle degeneration in patients with DMD, BMD, and FCMD. © 2001 John Wiley & Sons, Inc. Muscle Nerve 24: 399–402, 2001