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Paraneoplastic syndromes of the spinal cord, nerve, and muscle
Author(s) -
Rudnicki Stacy A.,
Dalmau Josep
Publication year - 2000
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/1097-4598(200012)23:12<1800::aid-mus3>3.0.co;2-x
Subject(s) - medicine , peripheral nervous system , spinal cord , cancer , pathology , peripheral , immunotherapy , nervous system , central nervous system , psychiatry
Cancer can affect the peripheral nervous system by non‐metastatic, sometimes immune‐mediated mechanisms. Recognition of these paraneoplastic syndromes is important because it can lead to the detection of the tumor, and also helps to avoid unnecessary studies to determine the cause of the neurologic symptoms in patients with cancer. Many paraneoplastic syndromes of the peripheral nervous system are not associated with serum antibodies that serve as markers of paraneoplasia. For this group of disorders the diagnosis depends on the clinician's index of suspicion and conventional electrophysiologic and laboratory tests. Treatment of the tumor, immunotherapy, or both may improve some of these syndromes. This review focuses on paraneoplastic syndromes of the spinal cord, peripheral nerve, and muscle. © 2000 John Wiley & Sons, Inc. Muscle Nerve 23: 1800–1818, 2000