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Functional properties of regenerating skeletal muscle following LIF administration
Author(s) -
Gregorevic Paul,
Hayes Alan,
Lynch Gordon S.,
Williams David A.
Publication year - 2000
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/1097-4598(200010)23:10<1586::aid-mus17>3.0.co;2-a
Subject(s) - leukemia inhibitory factor , skeletal muscle , myocyte , medicine , cytokine , regimen , dosing , myogenesis , systemic administration , regeneration (biology) , pharmacology , anesthesia , endocrinology , interleukin 6 , biology , in vivo , microbiology and biotechnology
Abstract We tested the hypothesis that periodic systemic administration of the myogenic cytokine leukemia inhibitory factor (LIF) enhances the functional recovery of regenerating skeletal muscle following bupivacaine‐induced degeneration. LIF had no effect on functional capacity or regenerating myofiber size in rat muscles at 7, 14, or 21 days post‐injury. The results do not support exogenous administration of LIF as a treatment for acute muscle injury, but a more frequent dosing regimen should be tested. © 2000 John Wiley & Sons, Inc. Muscle Nerve 23: 1586–1588, 2000