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Acquired slow‐channel syndrome
Author(s) -
Scola R.H.,
Werneck L.C.,
Iwamoto F.M.,
Comerlato E.A.,
Kay C.K.
Publication year - 2000
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/1097-4598(200010)23:10<1582::aid-mus16>3.0.co;2-h
Subject(s) - compound muscle action potential , medicine , repetitive nerve stimulation , acetylcholine receptor , weakness , stimulation , pyridostigmine , electromyography , snap , myasthenia gravis , electrophysiology , hand muscles , stimulus (psychology) , anesthesia , anatomy , receptor , physical medicine and rehabilitation , psychology , psychotherapist , computer graphics (images) , computer science
We report the case of a 37‐year‐old man with clinical and electrophysiological features of hereditary slow‐channel syndrome (SCS) and antibodies against acetylcholine receptors (AChR‐Abs). He presented with weakness of shoulder and hand muscles. A supramaximal single stimulus to the motor nerves disclosed a double compound muscle action potential (CMAP). Repetitive stimulation of ulnar, suprascapular, and median nerves showed a CMAP decrement greater than 10%. The patient responded to pyridostigmine. This report confirms the importance of AChR‐Ab titers in suspected cases of hereditary SCS because patients with positive AChR‐Abs may have a better response to available treatments. © 2000 John Wiley & Sons, Inc. Muscle Nerve 23: 1582–1585, 2000