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1 H and 13 C NMR spectral characterization of some antimalarial in vitro 3‐amino‐9‐methyl‐1 H ‐pyrazolo[3,4‐ b ]‐4‐quinolones
Author(s) -
Charris Jaime E.,
Domínguez José N.,
Lobo Gricela,
Cordero Mary I.,
López Simón E.,
Méndez Bernardo,
Pekerar Sara,
Riggione Flavia
Publication year - 2000
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/1097-458x(200012)38:12<1039::aid-mrc770>3.0.co;2-h
Subject(s) - chemistry , carbon 13 nmr , proton nmr , stereochemistry , in vitro , chemical shift , quinolone , plasmodium falciparum , biochemistry , antibiotics , malaria , immunology , biology
We report the 1 H NMR and 13 C NMR chemical shifts and J (H,H), J (H,F) and J (C,F) coupling constants of nine 3‐amino‐9‐methyl‐1 H ‐pyrazolo[3,4‐ b ]‐4‐quinolone derivatives, all of them active against Plasmodium falciparum in vitro . They were characterized and assigned on the basis of 1 H, 13 C and 13 C 1 H (short‐ and long‐range) correlated spectra. Copyright © 2000 John Wiley & Sons, Ltd.