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Slow inversion of stereoisomers of cyclic GABA analogues
Author(s) -
Gancarz Roman,
Latajka Rafał,
Halama Agnieszka,
Kafarski Paweł
Publication year - 2000
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/1097-458x(200010)38:10<867::aid-mrc741>3.0.co;2-1
Subject(s) - chemistry , ring flip , aqueous solution , stereochemistry , inversion (geology) , nuclear magnetic resonance spectroscopy , conformational isomerism , ring (chemistry) , ring size , nmr spectra database , computational chemistry , spectral line , organic chemistry , molecule , physics , astronomy , paleontology , structural basin , biology
In 31 P NMR spectra of derivatives of 1‐amino‐ and 1‐hydroxypiperid‐4‐ylphosphonic acids, fully reversible conformational equilibria in aqueous and methanolic solutions were observed. Depending on the pH of the medium and temperature, one or two phosphorus signals were observed indicating slow conformational ring interconversion under specific conditions. Copyright © 2000 John Wiley & Sons, Ltd.