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NMR spectral data for ester prodrugs of ganciclovir
Author(s) -
Gao Hongwu,
Mitra Ashim K.
Publication year - 2000
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/1097-458x(200008)38:8<696::aid-mrc655>3.0.co;2-6
Subject(s) - chemistry , prodrug , ganciclovir , carbon 13 nmr , proton nmr , stereochemistry , spectral analysis , organic chemistry , combinatorial chemistry , spectroscopy , biochemistry , human cytomegalovirus , gene , physics , quantum mechanics
A series of 9‐[(1,3‐dihydroxy‐2‐propoxy)methyl]guanine mono‐ and diesters, 2a–i , 3a–d and 4a–d , were synthesized as potential prodrugs of ganciclovir and both 1 H NMR and 13 C NMR spectra were assigned to these esters based on spectral comparison with compounds of similar structure. Copyright © 2000 John Wiley & Sons, Ltd.