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Direct measurement of heteronuclear long‐range coupling constants from phase‐sensitive HMBC spectra
Author(s) -
Ding Keyang
Publication year - 2000
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/1097-458x(200005)38:5<321::aid-mrc642>3.0.co;2-m
Subject(s) - heteronuclear molecule , homonuclear molecule , chemistry , pulse sequence , coupling constant , heteronuclear single quantum coherence spectroscopy , spectral line , phase (matter) , nuclear magnetic resonance , molecular physics , analytical chemistry (journal) , two dimensional nuclear magnetic resonance spectroscopy , nuclear magnetic resonance spectroscopy , stereochemistry , molecule , physics , quantum mechanics , organic chemistry
A simple pulse sequence in inverse‐detection mode is proposed for the detection of heteronuclear long‐range couplings. In the resulting 2D heteronuclear multiple‐bond correlation (HMBC) spectra, pure‐absorptive peak patterns are obtained along both frequency dimensions. Since the heteronuclear couplings result in anti‐phase splittings over the proton homonuclear multiplets along the ω 2 ‐dimension, the phase‐sensitive HMBC experiment can be provided as an easy and direct means for the measurement of heteronuclear long‐range coupling constants. Copyright © 2000 John Wiley & Sons, Ltd.