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Automated depth‐scanning confocal Raman microspectrometer for rapid in vivo determination of water concentration profiles in human skin
Author(s) -
Caspers P. J.,
Lucassen G. W.,
Bruining H. A.,
Puppels G. J.
Publication year - 2000
Publication title -
journal of raman spectroscopy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.748
H-Index - 110
eISSN - 1097-4555
pISSN - 0377-0486
DOI - 10.1002/1097-4555(200008/09)31:8/9<813::aid-jrs573>3.0.co;2-7
Subject(s) - raman spectroscopy , confocal , stratum corneum , resolution (logic) , analytical chemistry (journal) , chemistry , materials science , optics , chromatography , pathology , physics , medicine , artificial intelligence , computer science
An automated confocal Raman microspectrometer for rapid measurement of molecular concentration profiles in the skin is described. It permits the successive collection of Raman spectra at a range of depths below the skin surface. The axial resolution of the confocal Raman microspectrometer is 5.1±0.2 µm. The setup was applied to determine water concentration profiles of the stratum corneum and to determine changes therein as a result of hydration of the skin. Copyright © 2000 John Wiley & Sons, Ltd.