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Intermediate filament proteins define different glial subpopulations
Author(s) -
Yoshida Mika
Publication year - 2001
Publication title -
journal of neuroscience research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.72
H-Index - 160
eISSN - 1097-4547
pISSN - 0360-4012
DOI - 10.1002/1097-4547(20010201)63:3<284::aid-jnr1022>3.0.co;2-6
Subject(s) - glial fibrillary acidic protein , intermediate filament , rhombomere , intermediate filament protein , vimentin , hindbrain , biology , microbiology and biotechnology , gfap stain , neuroglia , central nervous system , neuroscience , astrocyte , cytoskeleton , hox gene , immunology , cell , genetics , immunohistochemistry , gene expression , gene
In certain species, specialized glial cells delineate cell domains in the central nervous system and assist in the elongation of axons by providing mechanical and chemical barriers. We showed previously, that the glial intermediate filament proteins vimentin and glial fibrillary acidic protein are extensively coexpressed in radial glia in the developing hindbrain, and that subsequently, the two proteins define distinct rhombomere domains: vimentin is localized in radial glia at the rhombomere boundaries and glial fibrillary acidic protein expression is restricted to the rhombomere centers (Yoshida and Colman [2000] J. Comp. Neurol. 424:47–57). The present study reveals that vimentin and glial fibrillary acidic protein continue to display distinct expression domains throughout the developing Xenopus central nervous system. Although the precise function of the two intermediate filaments in glial cells has yet to be revealed, the observations presented here suggests that glial intermediate filament proteins demarcate different populations of glial cells during nervous system development and that the existence of different glial populations may define glial boundaries. J. Neurosci. Res. 63:284–289, 2001. © 2001 Wiley‐Liss, Inc.